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The disease

Familial Hypercholesterolemia  

Familial Hypercholesterolemia (FH) is a hereditary dyslipidemia characterized by isolated and permanent elevated levels of circulating low-density lipoprotein (c-LDL).

An individual affected by FH has a 50% probability of having children developing FH.

Its prevalence is estimated at 1/300 to 1/500 in general population.

Familial Hypercholesterolemia is a worldwide healthcare issue*:

  • 10 million people are affected worldwide by Familial Hypercholesterolemia.
  • 200.000 patients will die prematurely from coronary heart disease.
  • ~ 80% of FH patients remain undiagnosed.
  • ~ 84% of FH patients do not take any lipid-lowering drug.

*Fernando Civeira. International Panel on Management of Familial Hypercholesterolemia. Guidelines for the diagnosis and management of heterozygous Familial Hypercholesteroleima. Atherosclerosis 173 (2004) 55-68.  

FH Diagnosis – Worldwide consensus

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